EOSINOPHIL SECRETION OF GRANULE-DERIVED CYTOKINES

Eosinophil secretion of granule-derived cytokines

Eosinophils are tissue-dwelling leukocytes, present in the thymus, and gastrointestinal and genitourinary tracts of healthy individuals at baseline, and recruited, often in large numbers, to allergic inflammatory foci Softballs and sites of active tissue repair.The biological significance of eosinophils is vast and varied.In health, eosinophils sup

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The influence of accounting internal control and human resources capacity on reliability and timeliness of regional government financial reporting (a study in Special Region of Yogyakarta Province)

Regional autonomy allows regions to hold the authority to manage their own regions.It also raises the responsibility that must be fulfilled by the regional government, namely financial reporting as a means of accountability.Reliability and timeliness are two important elements in financial information for the right decision making.There are several

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The Case for Laboratory Developed Procedures

An explosion of knowledge and technology is revolutionizing medicine and patient care.Novel testing must be brought to the clinic with safety and accuracy, but also in a timely and cost-effective manner, so that patients can benefit and laboratories can offer testing consistent with current guidelines.Under the oversight provided by the Clinical La

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Otoferlin acts as a Ca2+ sensor for vesicle fusion and vesicle pool replenishment at auditory hair cell ribbon synapses

Hearing relies on rapid, temporally precise, and sustained neurotransmitter release at the Polo Shirt ribbon synapses of sensory cells, the inner hair cells (IHCs).This process requires otoferlin, a six C2-domain, Ca2+-binding transmembrane protein of synaptic vesicles.To decipher the role of otoferlin in the synaptic vesicle cycle, we produced kno

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